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15 -- People who take the weight-loss drug rimonabant may face heightened risks for severe depression and anxiety, Danish researchers report. Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. Those trials compared taking rimonabant (20 milligrams a day) against a placebo. Rimonabant is not yet accustomed for use in the United States, area it is accepted as Zimulti. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA.

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